How long does it take to see results when using Differin Gel?

Differin Gel is formulated with Adapalene Retinoid, which works deep into pores in 5 minutes. When consistently applied to the full face, you may start to see results in as little as 1 week with best results after 12 weeks.

Can I use Differin Gel if I have sensitive skin?

Differin Gel includes Adapalene an ingredient shown to have improved tolerability resulting in less redness and skin irritation. Apply once daily to dry skin after cleansing. Stop use and consult a dermatologist if irritation becomes severe.

How often should I apply Differin Gel each day?

Use once daily (AM or PM). Clean skin gently and pat dry before applying. Cover the entire face with a thin layer. Do not use more than once a day. Applying more than directed will not provide faster or better results and may worsen skin irritation.

Can I use moisturizer with Differin Gel?

Moisturizing is essential in supporting the skin barrier when using Differin Gel and can help to combat excessive dryness or irritation. Apply Differin Gel to clean, dry skin then follow with non-comedogenic moisturizer and SPF in the AM.

Does Differin Gel cause purging or make acne worse before it gets better?

Acne may appear to worsen within the first few weeks of use as Differin Gel accelerates skin cell turnover. Continue treatment as directed; symptoms should subside between weeks 2-4. If severe irritation occurs stop use and consult dermatologist.

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Description

✨ Unlock your clearest skin yet with Differin’s Rx-strength magic!

DEEP PORE PENETRATION - Works within 5 minutes to clear and prevent acne at the source
GENTLE YET EFFECTIVE FORMULA - Water-based, oil-free, fragrance-free—perfect for sensitive, acne-prone skin
LONG TERM SKIN TRANSFORMATION - Normalizes skin cell turnover to improve tone, texture, and prevent scarring
CLINICALLY PROVEN ACNE REDUCTION - Up to 87% fewer breakouts in 12 weeks—real results you can trust
PRESCRIPTION STRENGTH POWER OTC CONVENIENCE - First FDA-approved retinoid available without a prescription

Differin Acne Treatment Gel delivers a powerful 0.1% adapalene retinoid formula clinically proven to reduce acne by up to 87% in 12 weeks. This dermatologist-recommended, fragrance-free gel penetrates deep into pores to clear, treat, and prevent breakouts while being gentle enough for sensitive skin. With a 90-day supply in a convenient pump, it’s the first FDA-approved prescription-strength retinoid available over the counter, designed for lasting skin clarity and improved texture.

Specifications

ASIN	B07ZTN5N1V
Active Ingredients	Adapalene 0.1%
Brand	Differin
Brand Name	Differin
Container Type	Bottle
Customer Reviews	4.6 out of 5 stars 10,079 Reviews
Global Trade Identification Number	00302994910403
Item Form	Gel
Item Type Name	Retinoid
Item Weight	45 Grams
Manufacturer	Galderma
Manufacturer Part Number	0299.491040
Material Features	Fragrance Free, Non-Comedogenic
Model Number	0299.491040
Product Benefits	Anti-Acne
Scent	Unscented
Scent Name	Unscented
Set Name	Style/Size Set
Size	45g (90 Day Supply)
Skin Type	Acne-Prone, Combination, Normal
Special Ingredients	Retinoid
Target Use Body Part	Face
UPC	302994910403
Unit Count	1.6 Ounce

Reviews

L**S

26.01.2026

A**R

18.04.2026

I**U

2.04.2026

S**H

6.01.2026

M**A

6.04.2026

S**L

18.12.2025

J**R

27.04.2026

A**H

19.04.2026

P**T

5.02.2026

J**.

20.08.2022

A**A

10.03.2026

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Buy anything from 5,000+ international stores. One checkout price. No surprise fees. Join 2M+ shoppers on Desertcart.

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In stock

Sold byAmazon MexicoDelivered byDesertcartCustomer service byDesertcartReturns14 days · 30 with PRO

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